![]() ![]() The first universal antidote was mithridate, in which after taking it an increasingly strong dose response was induced. In the 1st century AD, Galen (129–200) confirmed that the ingredients of the antidote, which Mithridates VI took in less and less diluted doses to become resistant to poisons, was a preparation mix produced by Medea in Colchis. They still grow in Georgia, such as: autumn crocus ( Colchicum autumnale), hemlock ( Conium maculatum), cowbane ( Cicuta vulgaris vel virosa), belladonna ( Atropa belladonna), black henbane ( Hyoscyamus niger) and white veratrum ( Veratrum album). She produced poisons and medicines from local plants. ![]() Some light is shed on its composition by the myth of the Argonauts’ expedition to the land of Aja (identical to Colchis), where an enchantress Medea lived. Its inhabitants were able to produce plant extracts and thicken them into a concentrate called ‘the poison’ and used in high dilutions as a medicine. Among the territories he conquered, the most important was Colchis (a region of today’s Georgia), providing the Kingdom of Pontus with human resources and raw materials. Tradition attributes its invention to Mithridates VI (135–63 BC), the king of Pontus, but this is a simplification. The term ‘antidote’ comes from the Greek word ἀντίδoτoν (antídoton), derived from ἀντί (antí, ‘against’) and δίδωμι (dídōmi, ‘I give’). ![]()
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